Ann Pharmacother. 2001 Jul-Aug;35(7-8):874-6. Burning mouth syndrome after taking clonazepam. Culhane NS(1), Hodle AD. Author information: (1)Pharmacy Practice, Nesbitt School of Pharmacy, Wilkes University, Wilkes-Barre, PA, USA. . OBJECTIVE: To report the first published case of.
Although uncommon, clinicians should be aware of this potential adverse effect due to the widespread use of benzodiazepines. This is the first published report describing BMS with a benzodiazepine.
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The association between clonazepam and BMS was highly probable according to the Naranjo probability scale. Paradoxically, clonazepam has been studied for the treatment of BMS and has demonstrated mild to moderate improvement. Candidiasis, anemia, menopause, diabetes mellitus, medications, anxiety, and depression are some causes of this syndrome. In this patient, underlying causes of BMS were eliminated when possible. The clinical presentation of BMS includes burning and painful sensations of the mouth in the absence of mucosal abnormalities.
As clonazepam was discontinued, the symptoms resolved. Clonazepam was discontinued, and the burning mouth symptoms compley resolved. Clonazepam significantly relieved her symptoms, but after four weeks of therapy, she reported a constant, mild, oral burning sensation. A 52-year-old white woman presented to the clinic with burning mouth symptoms. Since no other medications relieved the anxiety and panic symptoms, the patient requested clonazepam to be reinitiated, but she again developed intolerable burning mouth symptoms. The patient was previously maintained on alprazolam therapy for anxiety, but was switched to clonazepam because of increased anxiety and panic. The clonazepam dose was reduced, and the symptoms decreased, but remained intolerable. An oral examination was negative for mucosal abnormalities, and laboratory tests were unremarkable.
To report the first published case of clonazepam-induced burning mouth syndrome (BMS).
National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA. National Center for Biotechnology Information, U.S.
Your doctor and pharmacist should discuss several precautions of clonazepam (Klonopin) with you before you take it. These include:Do not take clonazep.
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How is clonazepam used?
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These include:. Your doctor and pharmacist should discuss several precautions of clonazepam (Klonopin) with you before you take it.
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As always, you should consult with your healthcare provider about your specific health needs. It should not be used for medical advice, diagnosis or treatment. Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view.