Keppra (levetiracetam) Injection is an antiseizure (antiepileptic) drug (AED) for adult patients (16 years and older) in the treatment of partial onset seizures when oral administration is temporarily not feasible. Keppra is used with other medications in adults with epilepsy.
The adverse reaction data presented below was obtained from a pooled analysis of two controlled pediatric clinical studies using an oral formulation in pediatric patients 4 to 16 years of age with partial onset seizures. The most common adverse reactions in pediatric patients receiving KEPPRA in combination with other AEDs, for events with rates greater than placebo, were fatigue, aggression, nasal congestion, decreased appetite, and irritability.
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Table 5: Adverse Reactions in Pooled Placebo-Controlled, Add-On Studies in Pediatric Patients Ages 4 to 16 Years Experiencing Partial Onset Seizures KEPPRA (N=165) % Placebo (N=131) % Headache 19 15 Nasopharyngitis 15 12 Vomiting 15 12 Somnolence 13 9 Fatigue 11 5 Aggression 10 5 Abdominal Pain Upper 9 8 Cough 9 5 Nasal Congestion 9 2 Decreased Appetite 8 2 Abnormal Behavior 7 4 Dizziness 7 5 Irritability 7 1 Pharyngolaryngeal Pain 7 4 Diarrhea 6 2 Lethargy 6 5 Insomnia 5 3 Agitation 4 1 Anorexia 4 3 Head Injury 4 0 Constipation 3 1 Contusion 3 1 Depression 3 1 Fall 3 2 Influenza 3 1 Mood Altered 3 1 Affect Lability 2 1 Anxiety 2 1 Arthralgia 2 0 Confusional State 2 0 Conjunctivitis 2 0 Ear Pain 2 1 Gastroenteritis 2 0 Joint Sprain 2 1 Mood Swings 2 1 Neck Pain 2 1 Rhinitis 2 0 Sedation 2 1 *Adverse reactions occurred in at least 2% of pediatric KEPPRA-treated patients and occurred more frequently than placebo-treated patients.
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Last reviewed on RxList 01/19/2017.
Keppra may interact with other antiepileptic drugs.
GENERIC NAME: FOSPHENYTOIN - INJECTION (foss-fen-eh-TOE-in). BRAND NAME(S): Cerebyx. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert. USES: Fosphenytoin is an anticonvulsant, it is used to treat or prevent seizures.
NOTES: Laboratory and/or medical tests may be performed to monitor your progress.
DRUG INTERACTIONS: l your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially: other seizure drugs (e.g., carbamazepine, valproic acid, phenobarbital), "blood thinners" (e.g., warfarin ), corticosteroids (e.g., prednisone ), hormone replacement therapy (e.g., estrogens ), rifamycin antibiotics (e.g., rifampin, rifabutin ), heart drugs (e.g., quinidine, amiodarone, nifedipine, digoxin, dopamine ), vitamin supplements (e.g., vitamin D, folic acid ), azole antifungal drugs (e.g., ketoconazole, itraconazole ), anti-ulcer drugs (e.g., cimetidine, omeprazole, sucralfate ), antidepressant drugs (e.g., amitriptyline, trazodone, fluoxetine ), NSAIDs (e.g., ibuprofen, phenylbutazone ), certain diabetes medications (e.g., diazoxide, tolbutamide), sulfa drugs (e.g., sulfamethoxazole ), trimethoprim, chloramphenicol, disulfiram, doxycycline, anti- cancer drugs, methadone, chlordiazepoxide, metyrapone, pyrimethamine, xanthines (e.g., theophylline, aminophylline), levodopa, cyclosporine, isoniazid, capecitabine.
INTRODUCTION. Ropivacaine is a long acting amide-type local anaesthetic (LA) with fewer central nervous system (CNS) and cardiovascular (CV) toxicity in animals or humans than bupivacaine.[1,2] However, a few neurological events have been reported after accidental intravascular [IV] administration of ropivacaine.
Ropivacaine is a long acting amide-type local anaesthetic (LA) with fewer central nervous system (CNS) and cardiovascular (CV) toxicity in animals or humans than bupivacaine. Here, we present a report of seizures following an accidental IV administration of ropivacaine through an epidural catheter. However, a few neurological events have been reported after accidental intravascular administration of ropivacaine.
Treatment is primarily supportive. Intravenous administration of thiopentone (50-100 mg) midazolam (2-5 mg) and propofol (1 mg/kg) can terminate seizures from systemic local anaesthetic toxicity.
Upon arrival at the hospital, 73 percent of patients were seizure-free (with intramuscular injection) whereas only 63 percent were seizure-free (with IV injection). Patients treated with midazolam (intramuscular injection) were also less likely to require hospitalization than the IV injection group. Among those.
As one might imagine, it can be very difficult to place an IV into someone having a seizure, thus wasting valuable time. Fortunay, new research has developed a pen-like mechanism – similar to an EpiPen for allergic reaction – which delivers anti-seizure medicine directly into the muscle, rather than through an IV. This type of seizure is one that lasts more than five minutes. One condition, termed status epilepticus, is of particular concern, as it causes 55,000 deaths each year. lorazepam). The usual treatment for status epilepticus is the IV delivery of anticonvulsant drugs (e.g.
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Diazepam (rectal) for stopping seizures This leaflet is about the use of rectal diazepam to stop seizures. (Seizures may also be called convulsions or fits.).
Although it can be upsetting to see your child having a seizure, it is important that you stay calm and follow the instructions.
NPPG, RCPCH and WellChild 2011,. Reviewed by: May 2018. Version 2, May 2015.
Please read this leaflet carefully. Keep it somewhere safe so that you can read it again. Our information sometimes differs from that provided by the manufacturers, because their information is usually aimed at adult patients. This leaflet has been written for parents and carers about how to use this medicine in children.
We use medicines to make our children better, but sometimes they have other effects that we don’t want (side-effects).
Have the medicine or packaging with you if you ephone for advice.