Long-term benzodiazepine use is not recommended because of lack of efficacy, as tolerance and dependence can occur, even at therapeutic doses. Other safety problems related to BZD use are a significant public health issue due to their pharmacodynamic effects on memory, attention, vigilance, and muscle relaxation.
Psychological dependence is considered to be accompanied by neuroplastic changes in the dopaminergic system, which projects from the ventral tegmental area (VTA) to the nucleus accumbens (NAc), and activation of the mesolimbic dopaminergic system is closely related to the reinforcing/rewarding effects and sensitization to locomotor activity induced by opioids and psychostimulants ( Fukakusa et al., 2008; Narita, Shibasaki, Mizuo, & Suzuki, 2003; Narita et al., 2004 ). While benzodiazepines are known to induce psychological dependence without increasing the release of dopamine from the NAc ( Invernizzi, Pozzi, & Samanin, 1991; Shibasaki, Masukawa, et al., 2013 ), the mechanisms by which benzodiazepines induce psychological dependence are not fully understood.
How much xanax affected my mental health. Unfortunay my anxiety has gotten the best of me and I've been using the clonazepam. I know benzodiazepines are not appropriate drugs for long term use. My trusty google ls me that valium--given it's long half life--may be one of the 'safer' benzos to take.
Thanks for commenting on your experience, all the best. I know it affects everyone differently but I'll keep this in mind if I ever get to the point of needing SSRI's.
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I've never had it prescribed to me but I've piggybacked off of my friends stash so that's how I know it works well for anxiety.
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How is etizolam compared to diazepam? I just read that etizolam doesn't crap on your memory/allows you to be more functional.
I am planning on taking diazepam on a daily basis as i have had enough of my anxiety (have had it for 10 years) I have read a lot of things online advising against taking benzos long term but it seems like the only effective treatment. Can someone please l me if it is ok to take diazepam daily indefiniy?.
I used to take for my 'anxiety' sometimes it worked great, sometimes not at all. What actually happens is you gain this false sense of confidence and self importance, seeing your self as super slick, when in reality your a slurring mess. Everyone is different. I'm sorry, but taking this stuff every day isn't the answer. But please stop after a few months because it's good to get a reality check every once and a while, as this can make some people go very out of character.
Benzodiazepines are remarkably safe, especially compared to most other sedatives and tranquilizers. They can be used by people with It is the first prescription sleeping pill approved for long-term use; in controlled studies, it has been found effective for up to six months. Still, some experts doubt whether.
(See the table below for some of those most widely used). They have a common basic chemical structure, and they all increase activity at receptors for the neurotransmitter gamma-aminobutyric acid (GABA). This transmitter inhibits the activity of neurons, slowing down the brain and nervous system, so benzodiazepines are relaxing and calming and promote sleep when taken at bedtime. As of late 2005, more than a dozen benzodiazepines are available by prescription. They differ mainly in how quickly they are absorbed, how long their effects last, and how long they take to leave the body.
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There is no link between long-term benzodiazepine use, defined as use for 6 months or longer, and increased deposition of beta-amyloid in the brain or cognitive decline in elderly patients who are without dementia, a small study suggests. "The take-home of this is that benzodiazepine use is not associated.
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