These tests give result for all benzodiazepine family drugs including: alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and more. Klonopin belong to the class of benzodiazepines drugs which are detectable on routine urine drug tests. Except urine tests, Klonopin can be also detected in blood, saliva and hair. The urine drug test that will detect Klonopin is the Xanax Drug Test / Valium Drug Test.
Many patients overdose this drug when they mix it with alcohol or opioids such as morphine or heroine. Combining Klonopin with opioids or other CNS depressants may cause following side effects:. It can also be dangerous to combine Klonopin with clozapine in some situations, as well as opioids and other drugs. If Klonopin is taken together with alcohol, serious interactions may occur resulting in a decrease in motor and mental function. This interaction can also significantly slow the respiratory system leading to slowed breathing, confusion and loss of consciousness. Overdose after Klonopin use is more likely to occur when this drug is taken together with alcohol or other drugs.
Only 7-ACLO metabolites of clonazepam can be detected in a saliva sample during 5 and 6 days after ingestion. Saliva tests are non-invasive; however their accuracy is suboptimal, because detection of clonazepam will be only available in the cases of overdose. However, the ability to detect 7-ACLO metabolites is much lower compared to other forms of testing. In this test 0.4 ml of oral fluid is collected from the mouth and then diluted with 0.8 ml of a preservative. This mixture is then analyzed with liquid chromatography/mass spectrometry (LC/MS). Thus, saliva testing is usually used as an alternative to urine testing in cases of acute overdose or abuse.
When overdosed patient get to emergency room, doctors and nurses will provide supportive care and adequate monitoring to ensure that they are safe. Although this this drug also carries some risks, it is highly effective at treating an overdose. If significant respiratory depression or coma is caused as a result of overdose, patients will be referred to the intensive care unit for further care. In the case of intentional overdose, they will surely undergo a psychiatric evaluation before leaving the hospital. Depending on how overdosed person recovers, he/she may stay in the emergency room until they are stabilized. Flumazenil is proved to be good antidote which can be administered in the hospital to neutralize the effects of an acute benzodiazepine overdose.
Klonopin is also sold through underground sources at parties, clubs or raves. The Internet becomes very easy place to get clonazepam/Klonopin without a prescription. Illicit online suppliers sell generic forms of this drug most commonly to young users in search of a suitable source of recreational drugs. On the streets, Klonopin is known by a number of slang terms such as: Kpin, Pin, Klons, Benzos, Tranks.
The DEA considers all benzodiazepines drugs including clonazepam from Klonopin to be Schedule IV drugs, meaning they are safe with a prescription and medical oversight. Klonopin is often used in nonmedical purposes and sold illegally. Thus, these drugs are not as closely monitored as prescription opioid drugs, which are Schedule II.
As a freelancer I write medical articles on Elance and Upwork. From the July of 2015 to January 2016 I worked in a pharmaceutical company Hemofarm a.d.(Member of STADA group) based in Vrsac, Serbia, as an expert associate for GMP compliance within the sector Quality Assurance. Tizanidine recreational use Polysporin powder. I am currently working in a pharmacy called Zivkovic in Negotin. My name is Miljan Krčobić. In June 2015 I graduated from the Faculty of Pharmacy in Belgrade and thus acquired the title Master of Pharmacy. I was born on 14th of November 1989. in Negotin, Serbia, where I finished elementary and high school.
Abusers often get Klonopin from a family member or friend having legitimate prescription. Family members may be the most common source of drugs including Klonopin. Benzodiazepines drugs such as: Ativan (lorazepam), Xanax (alprazolam), Valium (diazepam), but also Klonopin (clonazepam) are frequently prescribed and can be found in many households. A parent, without attending, might share prescription drugs without considering the potential for dangerous side effects and drug interactions.
Rendering its long elimination half-life it can be estimated that Klonopin is likely to stay in your system for about 7-9 days after the final dose is taken. It is necessary to consider the elimination half-life time of clonazepam in order to determine how long Klonopin will remain in your body after final dose is taken. If this is the case, it could take between 4-14 days for complete elimination of Klonopin. But, different sources suggest that clonazepam may have even a wider half-life range between 18.7 hours to 60 hours. Clonazepam has a long elimination half-life estimated beneath the range of 30 to 40 hours. According to this it will take about 1 to 2 days to eliminate the half of the taken dose from the body.
Signs and symptoms of a Klonopin overdose may include:
Those whose answer is ‘’yes’’ for one or more following question they can find themselves addicted to Klonopin and should seek for medical attention:
The larger number of prescriptions is the drugs are often the target of abuse since they are easy to find. Between 1999 and 2010, the number of benzodiazepines prescription enlarged 4 times. Adults between the ages of 18 – 64 were the major population and thousands of them got struggle to addiction or dependence due to a prescription for these medications. Even though, Klonopin is very efficient medicine that helped many patients, outside of a prescription, it can be very harmful for those who use it for non-medical reasons.
The vast majority of people overdosing on benzodiazepines used for nonmedical reasons are combining it with alcohol, narcotics, opiates, or other prescription drugs. For example, just in 2004, there were approximay 1.3 million emergency room cases linked to drugs overdose, of which about 40% of them were involved with nonmedical use of prescription drugs. According to medical reports, Klonopin is involved in a high percentage of drug-related episodes of overdose. 30% or 144,385 visits in 2004 were caused after benzodiazepines overdose, and almost 20% of the benzodiazepine patients which is about 26,238 patients were Klonopin overdoses.
Withdrawal symptoms of Klonopin will be manifested if drug is taken during long-term period and then suddenly abrupt. The severity and duration of Klonopin withdrawal symptoms depends on how much and how often Klonopin is taken and by individual factors such as your height, sex, weight, age, general health. According this period for Klonopin and similar benzodiazepines drugs is only 2 weeks.
May 26, 2017 Miljan Krcobic Drug Abuse 0 Contents.
Symptoms may include: seizures, anxiety, delirium, agitation, restlessness, psychosis, sweating, uncontrollable shaking, moodiness, behavioral changes, vomiting, tremor, rashes, stomach and muscle cramps, hallucinations, heart palpitations, loss of appetite, diarrhea or constipation, dry mouth, depression, hysteria and insomnia. These symptoms may vary from person to person and some find it relatively easy to withdraw. Klonopin withdrawal symptoms are similar to the ones for alcoholism and barbiturates. Withdrawal syndrome usually begins 24 – 72 hours after the last dose is taken. Most people need 2 weeks to achieve chemical detoxification from benzodiazepines. Some people have withdrawal symptoms for months. Symptoms seem to be more severe between 5th and 7th day. According to this, Klonopin withdrawal is considered as hard, if you know that heroin’s withdrawal lasts for about 3 days.
Many manufacturers now produce generic clonazepam. Klonopin is available in doses of 0.5 mg, 1 mg and 2 mg. FDA first approved clonazepam in 1975 under the brand name Klonopin, which was originally manufactured by Roche Drug Company. Klonopin is most commonly prescribed as an antiepileptic drug in the treatment of the Lennox-Gastaut syndrome (epileptic petit mal variant), akinetic and myoclonic seizures and for the treatment of panic disorders including agoraphobia. Clonazepam is used as anti-seizure medicine in adults and children. It also affects neurotransmitters in the brain that may be unbalanced in patients with anxiety disorders. This medicine comes in the forms of a tablet and disintegrating (dissolving) tablet to be taken by mouth. In many parts of the world it is commonly used as a recreational drug. Klonopin is a Brand name for an anxiolytic prescription medication that contains benzodiazepine drug clonazepam as an active ingredient.
“ Is Xanax and Klonopin (Clonazepam) the same thing? “ “ Is it safe to take ambien and klonopin together? ” “ Can you overdose on Tizanidine? “
Klonopin use should never be abruptly discontinued, no matter the drug is used for medical or non-medical purpose. Some of the drugs used to help people in withdrawal are buspirone, anti-seizure drugs and antidepressants. The ideal method to withdraw from Klonopin is to enter a residential treatment center and undergo detoxification with medical supervision. Klonopin discontinuation should be always followed and monitor by health professional with adequate dose reduction and tapering.
Here are some Klonopin ‘’high’’ experience described on Erowid website (https://erowid.org/):
Taking Klonopin with alcohol or other drugs can increase the risk of an overdose and death. Abusers often ground up and snort Klonopin talbets, or inject them after dissolving. Recreational users often combine Klonopin together with other drugs, such as narcotics, alcohol, tranquilizers or hallucinogenics. This way of use enhances the tranquilizing effects of other drugs and makes more stimulants high. Taking benzodiazepines with depressants like alcohol can slow down the activity of your brain to a very dangerous rate, increasing the risk of unconsciousness, coma or death.
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FDA approved, label indications, for Klonopin are:
Clonazepam is among the most abusive and addicted benzodiazepines drugs and the major reason for that is its rapid onset of action and a long elimination half-life time. Although it is prescription medicine, Klonopin is considered as top-ten most addictive and abusive sleeping aid. All benzodiazepines are known to have a high risk of dependence, tolerance and addiction thus the general recommendations is that these drugs should never be used for a long-term. This drug has fast absorption and passes through the brain in an hour, whereas it can stay in the body for close to 3 days, depending on the used dose, frequency of use and different individual factors. Thus, Klonopin and other clonazepam products are labeled to be prescribed only for no more than 2 weeks, considering that longer treatment will probably cause addiction and withdrawal. The reason for that is because Klonopin can produce a euphoric effects and high but also drowsy calmness sense that can be very pleasant and thus abusive. Because it’s effects start quickly, the body will speedily develop a tolerance and dependence on this drug. When you take Klonopin, your brain becomes depressed and this causes a short, but euphoric “high”.
The majority of Klonopin abusers and addicts actually have undiagnosed ahealth issues such as clinical depression, personality disorders, unresolved childhood traumas, etc. In order to achieve life free of drugs, they must learn to understand their pain, and to deal with with it and everyday life without using any drug. Many drug abusers take drug to self-medicate emotional pain. If some psychiatric disorder is diagnosed, such disorders need to be treated along with addiction they will be much more likely to go back into drug abuse after addiction treatment. the In order to find best way to help such cases to let go of addiction, these patients undergo a complete physical and psychological examination for determination.
Final results are increased inhibition of the ascending reticular activating system. Clonazepam which is the active ingredient of Klonopin, works by causing allosteric interactions between benzodiazepine receptors and GABA – gamma-aminobutyric acid receptors in the CNS, increasing the effects of neurotransmitter – GABA, which is the major inhibitory neurotransmitter in the CNS.
Moreover, clonazepam is highly lipophilic drug and it can be accumulated in fat tissues, so drug traces may appear in blood for longer durations. Since blood tests are invasive and have shorter time of detection than urine tests, they are often reserved for a hospitalized patient or in cases where a urine sample cannot be attained. Klonopin can be easiest detected in blood after 1-2 hours of administration. Due to clonazepam’s long elimination half-life, it will probably stay detectable in blood some days after ingestion.
Moreover, it is essential to bear in mind that clonazepam is metabolized within the liver into a metabolite known as 7-aminoclonazepam. The elimination half-life of 7-aminoclonazepam is either shorter than, or similar to that of clonazepam. According to all of this, the time needed for fully elimination of clonazepam and its metabolite 7-aminoclonazepam can be expected after 2 weeks of discontinuation.
But new findings suggest that 7-ACLO metabolite can be detected in urine for a much longer time, according to one study for more than 3-4 weeks. Because of longer detetction-time period, urine tests are often more preferred than blood tests. Higher dose and chronic users of Klonopin may have 7-ACLO positive tests for more than a month. Urine tests are also more convenient, they are non-invasive, and fast. According to some data 7-ACLO metabolite stay detectable within urine for up to 5 days post-ingestion of a single dose. Because of that, most urine analyses measure amounts of its metabolite 7-amino-clonazepam or shortly 7-ACLO. About 2% of a clonazepam taken dose is excreted unchanged with urine.
The first line of addiction treatment is intense counseling. These professionals can help you understand the primary cause of addiction, how to manage desires, and how to achieve abstinence on a long-term basis. Life changes will be necessarily. Those who enter residential center will have their own counselor to help them understand themselves. Most residential treatment centers offer parties, sports, sight-seeing and other recreational activities. Once addicts return home, they will probably continue in individual counseling and support meetings within their community. These treatment programs are usually fun, and addicts are also learning how to relax and enjoy life without drugs.
I also take 50 mg zoloft every day but my m.d. Colors are brighter and sound prettier, a slight ‘body high’ where all of my being feels wrapped in a warm blanket that nuzzles and comforts me. I feel like my apartment is the physical embodiment of all the beauty in my life and I get to walk around it and be immersed in the peace that is really inside me… I really want to sink into the cloud of my bed that makes me feel so comfortable and so safe on nights like these. However, if I should drift into sleep, it would be peaceful and full of dreams I am sure (clonazepam does that to me). I’m gonna up the ante a little bit and take 4 more 1 mg pills. I’m getting thirsty. hooked up (however ghetto like of a hook-up it is). The euphoria is more intense, but the drowsiness isn’t really drowsiness, just the imminent need to cuddle up in my bed with happy thoughts. I can definiy feel the effects of the other 4 mg. I’m gonna go relax now that I have my t.v. It is at once a physical and emotional feeling. The thing about clonazepam is that the drowsiness doesn’t hit until the end of the night. At 8:11pm starting to have a bit more difficult time typing and concentrating. It should be interesting to coordinate my movements, we’ll see how it goes. One more thing, I talked on the ephone to my friend a minute ago, and it was very genial but I was having a hard time communicating cuz she kept saying, ‘What?? I can’t understand you?’ And I couldn’t really understand her either. It will probably take me another hour or two to fall asleep but I am definiy not capable of typing any more. Winding down, drowsiness is starting to overcome me, I’m heading for bed and I’m sure these relaxed effects will continue well into tomorrow after I wake up. Nonetheless it was friendly. “…I took six 1 mg clonazepam tablets at 7:51pm. I’ll get back to you in a little bit. My head feels swimmy, and colors look a bit brighter… At 8:31pm I feel a simple, basic connectedness to the things around me and take even more pleasure in the small things than I usually do, like the smell of my apple-cinnamon bathroom air-freshener even… At 8:45pm The euphoria is beginning. said these two won’t interact with each other. Well, when the tv fell on my foot instead of cursing like I normally would, I laughed really loud. “.
These factors include: age, body mass, percentage of fats, genetics, metabolic rate, liver function, co-administration of food or drugs, urinary pH, dosage and frequency of use. Different factors may influence how long clonazepam will stay in your system.
Many health professionals suggest that addiction is also a behavioral disorder, and that genetics may play important role in its development. Addiction has psychological nature and occurs when the drug use motivates its continuing. Patients who were using Klonopin for medical purposes and with prescriptions, in appropriate amounts and as recommended by the doctor will need to go through withdrawal symptoms and may for certain built up a tolerance to the drug, but this does not have to be that patients is necessarily addicted. The addict has no choice but to keep using Klonopin. Klonopin addiction and Klonopin physical dependency is not the same thing.
This method is often used by law enforcement agents to detect clonazepam used in the case of a drug-related crime. The biggest disadvantage is that they can’t detect the drug if it is recently taken. Hair samples (15-20 follicles) are collected from a victim and then send to the lab analysis with gas chromatography/mass spectrometry (GC/MS). It has been showed that hair tests are able to detect 7-ACLO metabolite after a period of 4 month of post-ingestion. Days or weeks of Klonopin post-ingestion are needed for the drug metabolites to appear in the hair.Clonazepam 0.5 mg overdose